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Authors: Kjellberg A, De Maio A, Lindholm P PMID: 33254531 PMCID: PMC7456590 DOI: 10.1016/j.mehy.2020.110224 Abstract Introduction: SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute [...]
Categories: I-RECOVER Post-Vaccine
Authors: Le Balc'h P, Pinceaux K, Pronier C, Seguin P, Reizine F PMID: 32859241 PMCID: PMC7453668 DOI: 10.1186/s13054-020-03252-3 Abstract The SARS-CoV-2 infection can lead to severe acute respiratory distress syndrome (ARDS) with prolonged mechanical ventilation (MV). Patients with coronavirus disease 2019 (COVID-19) associated ARDS usually met the diagnosis criteria for sepsis-associated immunosuppression as acquired infections, [...]
Categories: I-RECOVER Post-Vaccine, MATH+
Authors: Bortolotti D, Gentili V, Rizzo S, Rotola A, Rizzo R PMID: 32859121 PMCID: PMC7563485 DOI: 10.3390/cells9091975 Abstract Natural killer cells are important in the control of viral infections. However, the role of NK cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has previously not been identified. Peripheral blood NK cells from SARS-CoV [...]
Categories: I-RECOVER Post-Vaccine
Tags: SARS-CoV-2
Authors: Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M PMID: 32873420 DOI: 10.1016/j.npep.2020.102083 Abstract Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid [...]
Categories: I-RECOVER Long Covid, I-RECOVER Post-Vaccine
Tags: autophagy, spermidine
Authors: De Flora S, Balansky R, La Maestra S PMID: 32780893 PMCID: PMC7436914 DOI: 10.1096/fj.202001807 Abstract COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has [...]
Categories: I-CARE Early Covid, I-RECOVER Long Covid, I-RECOVER Post-Vaccine, MATH+
Tags: COVID-19, N-Acetylcysteine
Authors: Gucyetmez B, Atalan HK, Sertdemir I, Cakir U, Telci L PMID: 32771054 PMCID: PMC7414262 DOI: 10.1186/s13054-020-03215-8 Abstract In patients with COVID-19 pneumonia, high risk of thrombosis became a current issue, and D-dimer levels indicating fibrin degradation products (FDPs) in the plasma were found as a predictor for mortality. Although unfractionated heparin (UFH) and low-molecular-weight [...]
Categories: I-RECOVER Post-Vaccine, MATH+
Authors: Morath C, Weigand MA, Zeier M, Speer C, Tiwari-Heckler S PMID: 32753056 PMCID: PMC7399583 DOI: 10.1186/s13054-020-03171-3 Abstract The spectrum of coronavirus disease 2019 (COVID-19) ranges from asymptomatic infection to respiratory failure and death of patients. Severely affected patients may develop a cytokine storm-like clinical syndrome with multi-organ failure and a mortality rate of up [...]
Categories: I-RECOVER Post-Vaccine, MATH+
Authors: Hannan A, Rahman A, Rahman S, Sohag AA, Dash R, Uddin J. PMID: 32659267 PMCID: PMC7351063 DOI: 10.1016/j.imlet.2020.07.001 Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat to public health across the world. Although there is no clear gender or [...]
Categories: I-RECOVER Long Covid, I-RECOVER Post-Vaccine
Tags: autophagy, intermittent fasting, SARS-CoV-2
Authors: Fakhar-e-Alam Kulyar M, Li R, Mehmood K, Waqas M, Li K, Li J PMID: 32773257 PMCID: PMC7347483 doi: 10.1016/j.phymed.2020.153277 Abstract The world is witnessing a difficult time. The race of developing a new coronavirus (COVID-19) vaccine is becoming more urgent. Many preliminary studies on the pathophysiology of COVID-19 patients have provided some clues to [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19, Nagella Sativa
Authors: Santamarina MG, Boisier D, Contreras R, Baque M, Volpacchio M PMID: 32631389 PMCID: PMC7338110 DOI: 10.1186/s13054-020-03125-9 Abstract In December 2019, a novel human coronavirus, SARS-CoV-2, was detected in the city of Wuhan, China, which since then has expanded throughout the world and caused a pandemic coronavirus disease (COVID-19). SARS-CoV-2 binds to angiotensin-converting enzyme 2 [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19