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Authors: Cereda G, Ciappolino V, Boscutti A, Cantu F, Enrico P, Oldani L PMID: 34634109 PMCID: PMC8524565 DOI: 10.1093/advances/nmab110 Abstract The outbreak of the pandemic associated with Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) led researchers to find new potential treatments, including nonpharmacological molecules such as zinc (Zn2+). Specifically, the use of Zn2+ as a [...]
Categories: I-RECOVER Post-Vaccine
Authors: Patterson B, Yogendra R, Guevara-Coto J, Osgood E, Bream J, Parikh P DOI:10.21203/rs.3.rs-1344323/v1 Abstract Post-acute sequelae of COVID (PASC), or long COVID, is a multisystem complication of SARS-CoV-2 infection that continues to debilitate millions worldwide thus highlighting the public health importance of identifying effective therapeutics to alleviate this illness. The [...]
Categories: I-RECOVER Post-Vaccine
Tags: long COVID, Maraviroc, Pravastatin
Authors: Gutierrez-Castrellon P, Gandara-Marti T, Abreu AT, Nieto-Rufino CD, Lopez-Orduna E PMID: 35014600 PMCID: PMC8757475 DOI: 10.1080/19490976.2021.2018899 Abstract Intestinal bacteria may influence lung homeostasis via the gut-lung axis. We conducted a single-center, quadruple-blinded, randomized trial in adult symptomatic Coronavirus Disease 2019 (Covid19) outpatients. Subjects were allocated 1:1 to probiotic formula (strains Lactiplantibacillus plantarum KABP022, KABP023, [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19
Authors: Izquierdo JL, Soriano JB, Gonzalez Y, Lumbreras S PMID: 35084258 PMCID: PMC8795755 DOI: 10.1177/00368504221074574 Abstract Infection by SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) can be associated with serious and life-threatening conditions, including acute respiratory distress syndrome (ARDS). Severity and mortality have been related to a cytokine storm, an imbalance of oxidative stress, and a [...]
Categories: I-CARE Early Covid, I-RECOVER Long Covid, I-RECOVER Post-Vaccine, MATH+
Tags: COVID-19, N-Acetylcysteine
Authors: Patterson BK, Francisco EB, Yogendra R, Long E, Pise A, Hall E et al. PMID: 35082777 PMCID: PMC8784688 DOI: 10.3389/fimmu.2021.746021 AbstractThe recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to 30% of all infected [...]
Categories: I-RECOVER Long Covid, I-RECOVER Post-Vaccine
Tags: COVID-19
Authors: Rondanelli M, Perna S, Gasparri C, Petrangolini G, Cavioni A, Peroni G. PMID: 35054459 PMCID: PMC8780248 DOI: 10.3390/life12010066 Abstract Quercetin, for its crucial properties, fulfills the need for a multifactor action that is useful for the potential counterbalance of a COVID-19 infection. Given this background, the aim of the study was to evaluate the [...]
Categories: I-CARE Early Covid, I-PREVENT, I-RECOVER Post-Vaccine
Tags: quercetin
Authors: Santamarina MG, Beddings I, Martinez Lomakin F, Boisier Riscal D PMID: 34980198 PMCID: PMC8721481 DOI: 10.1186/s13054-021-03885-y Abstract Background: SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation-perfusion mismatch that can be characterized using subtraction computed tomography angiography (sCTA). This study aims to evaluate [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19, Sildenafil
Authors: Pretorius E, Venter C, Laubshder G, Kotze M, Moremi K doi: https://doi.org/10.21203/rs.3.rs-1205453/v1 Abstract We recognise that fibrin(ogen) amyloid microclots and platelet hyperactivation, that we have previously observed in COVID-19 and Long COVID/Post-Acute Sequelae of COVID-19 (PASC) patients, might form a suitable set of foci for the clinical treatment of the symptoms of long COVID/PASC. [...]
Categories: I-RECOVER Post-Vaccine
Tags: long COVID
Authors: Sabel BA, Zhou W, Huber F, Schmidt F, Sabel K PMID: 34924406 PMCID: PMC8764598 DOI: 10.3233/RNN-211249 Abstract Background: An effective treatment is needed for long-COVID patients which suffer from symptoms of vision and/or cognition impairment such as impaired attention, memory, language comprehension, or fatigue. Objective: Because COVID-19infection causes reduced blood flow which may cause [...]
Categories: I-RECOVER Post-Vaccine
Authors: Parhiz H, Brenner JS, Patel PN, Papp TE, Li Q, Shi R PMID: 34953981 PMCID: PMC8695324 DOI: 10.1016/j.jconrel.2021.12.027 Abstract Current nucleoside-modified RNA lipid nanoparticle (modmRNA-LNP) technology has successfully paved the way for the highest clinical efficacy data from next-generation vaccinations against SARS-CoV-2 during the COVID-19 pandemic. However, such modmRNA-LNP technology has not been characterized [...]
Categories: I-RECOVER Post-Vaccine
Tags: Inflammation Exacerbation, mRNA