Categories
Tags
Authors: Thomas R, Aldous J, Forsyth R, Chater A, Williams M. DOI: 10.29011/2577-1515.100182 Abstract Background: Gut microfloral dysbiosis is known to affect the majority individuals suffering with a Covid-19 infection. This study evaluated whether a specific lactobacillus and inulin blend, which aimed to improve gut health, could reduce the severity of early and chronic Covid-19 [...]
Categories: I-CARE Early Covid, I-PREVENT, I-RECOVER Post-Vaccine
Tags: COVID-19
Authors: Holford P, Carr AC, Zawari M, Vizcaychipi MP PMID: 34833042 PMCID: PMC8624950 DOI: 10.3390/life11111166 Abstract Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin. Administration of intravenous vitamin C [...]
Categories: I-RECOVER Post-Vaccine
Authors: Olajide O, Iwuanyanwu VU, Adegbola OD, Al-Hindawi AA PMID: 34709564 PMCID: PMC8551352 DOI: 10.1007/s12035-021-02593-6 Abstract In addition to respiratory complications produced by SARS‐CoV‐2, accumulating evidence suggests that some neurological symptoms are associated with the disease caused by this coronavirus. In this study, we investigated the effects of the SARS‐CoV‐2 spike protein S1 stimulation on [...]
Categories: I-RECOVER Post-Vaccine
Tags: Neuroinflammation, SARS-CoV-2
Authors: Siegert A, Diedrich L, Antal A PMID: 34776903 PMCID: PMC8578968 DOI: 10.3389/fnhum.2021.730134 Abstract The world's population is aging. With this comes an increase in the prevalence of age-associated diseases, which amplifies the need for novel treatments to counteract cognitive decline in the elderly. One of the recently discussed non-pharmacological approaches is transcranial direct current [...]
Categories: I-RECOVER Post-Vaccine
Tags: tDCS
Authors: Teselink J, Bawa KK, Koo GK, Sankhe K, Liu CS, Oh P PMID: 34700007 DOI: 10.1016/j.arr.2021.101499 Abstract Background: Non-invasive brain stimulation (NIBS) techniques have shown some promise in improving cognitive and neuropsychiatric symptoms (NPS) in people with Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI). However, data from clinical trials involving [...]
Categories: I-RECOVER Post-Vaccine
Tags: Alzheimer's Disease
Authors: Tran HT, Gigl M, Le NP, Dawid C, Lamy E PMID: 34681279 PMCID: PMC8538008 DOI: 10.3390/ph14101055 Abstract To date, there have been rapidly spreading new SARS-CoV-2 "variants of concern". They all contain multiple mutations in the ACE2 receptor recognition site of the spike protein, compared to the original Wuhan sequence, which is of great [...]
Categories: I-CARE Early Covid, I-RECOVER Post-Vaccine
Tags: ACE2 protein, COVID-19, dandelion, SARS-CoV-2
Authors: Hasan ZT, AlAtrakji MQ, Mehuaiden AK PMID: 34653660 PMCID: PMC8506572 DOI: 10.1016/j.ijid.2021.10.012 Abstract Objectives: This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19). Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19, Melatonin, Sepsis, Thrombosis
Authors: Clough E, Chean KT, Inigo J, Tubbesing KE, Chandra D, Chaves L PMID: 34599743 PMCID: PMC8487226 DOI: 10.1007/s11481-021-10015-6 Abstract Emerging clinical data from the current COVID-19 pandemic suggests that ~ 40% of COVID-19 patients develop neurological symptoms attributed to viral encephalitis while in COVID long haulers chronic neuro-inflammation and neuronal damage result in a [...]
Categories: I-RECOVER Post-Vaccine
Authors: Kakavas S, Karayiannis D, Mastora Z PMID: 34684460 PMCID: PMC8537261 DOI: 10.3390/nu13103458 Abstract There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19, Histamine, Immunonutrition, Mast Cells
Authors: Marik P, Iglesias J, Varon J, Kory P PMID: 34569339 PMCID: PMC8477699 DOI: 10.1177/20587384211048026 Abstract COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-19 is probably amongst the most complex of medical conditions known to medical science. While enormous strides have been made in understanding the molecular pathways involved in patients [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19, pathophysiology