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Authors: Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnager T PMID: 33093056 PMCID: PMC7578662 DOI: 10.1136/bmj.m3939 Abstract Objective: To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India. Design: Open label, parallel arm, phase II, multicentre, randomised controlled trial. Setting: 39 [...]
Categories: MATH+
Tags: COVID-19
Authors: Stone JH, Frigault MJ, Sterling-Boyd NJ, Fernandes AD, Harvey FL PMID: 33085857 PMCID: PMC7646626 DOI: 10.1056/NEJMoa2028836 Abstract Background: The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. Methods: We performed a randomized, double-blind, placebo-controlled trial involving patients with confirmed severe acute [...]
Categories: MATH+
Tags: COVID-19, Tocilizumab
Authors: Villa G, Romagnoli S, De Rosa S, Greco M, Resta M PMID: 33046113 PMCID: PMC7549343 DOI: 10.1186/s13054-020-03322-6 Abstract Background: Systemic inflammation in COVID-19 often leads to multiple organ failure, including acute kidney injury (AKI). Renal replacement therapy (RRT) in combination with sequential extracorporeal blood purification therapies (EBP) might support renal function, attenuate systemic inflammation, [...]
Categories: MATH+
Authors: Chamie J Abstract In these eight Peruvian State analyses, Ivermectin distributions preceded sound reductions in excess deaths and case fatality rate (CFR). The variation in the number of detected cases nor the vulnerable population decrease can explain this reduction. Other possible explanations, such as cross-immunity with dengue, or mere causality, have been discarded due [...]
Categories: I-CARE Early Covid, MATH+
Tags: COVID-19, ivermectin
Introduction: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine. Methods: Retrospective, propensity-matched observational study of consecutive COVID-19-positive patients between February 24, 2020, and May 13, 2020.
Categories: MATH+
Tags: Famotidine
Authors: Rawson TM, Wilson RC, Holmes A PMID: 32979569 PMCID: PMC7546203 DOI: 10.1016/j.cmi.2020.09.025 Abstract The novel coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has placed an unprecedented strain on healthcare systems. An emerging concern is the potential impact of the novel coronavirus SARS-CoV-2 pandemic on antimicrobial resistance (AMR). [...]
Categories: MATH+
Authors: Dequin PF, Heming N, Meziani F, Plantefeve G, Voiriot G PMID: 32876689 PMCID: PMC7489432 DOI: 10.1001/jama.2020.16761 Abstract Importance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option. Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute [...]
Categories: MATH+
Tags: COVID-19, Hydrocortisone
Reference: Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19.
Authors: Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, et al. PMID: 32876697 PMCID: PMC7489418 DOI: 10.1001/jama.2020.17022 Abstract Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, setting, and participants: An ongoing adaptive platform trial testing [...]
Categories: MATH+
Tags: COVID-19, Hydrocortisone
Authors: Buijsers B, Yanginlar C, de Nooijer A, Grondman I, Jonkman I, Rother N PMID: 33123154 PMCID: PMC7573491 DOI: 10.3389/fimmu.2020.575047 Abstract Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation. Low molecular weight [...]
Categories: MATH+
Tags: COVID-19