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Authors: Tomazini BM, Maia IS, Cavalcanti AB, Berwanger O, Rosa RG, Veiga VC PMID: 32876695 PMCID: PMC7489411 DOI: 10.1001/jama.2020.17021 Abstract Importance: Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these patients. Objective: To determine [...]
Categories: MATH+
Authors: Jonathan A C Sterne, Srinivas Murthy, Janet V Diaz, et al. PMID: 32876694 PMCID: PMC7489434 DOI: 10.1001/jama.2020.17023 Abstract Importance: Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support. Objective: To estimate the [...]
Categories: MATH+
Tags: Corticosteroids, COVID-19
Authors: Lehrer S, Rheinstein PH PMID: 32871846 PMCID: PMC7652439 DOI: 10.21873/invivo.12134 Abstract Background/aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One drug that has attracted interest is the antiparasitic compound ivermectin, a macrocyclic lactone derived from the bacterium Streptomyces avermitilis. We carried out a docking [...]
Categories: I-CARE Early Covid, I-RECOVER Post-Vaccine, MATH+
Tags: ACE2 protein, ivermectin, SARS-CoV-2
Authors: Schurink B, Roos E, Radonic T, Barbe E, Bouman CS DOI:https://doi.org/10.1016/S2666-5247(20)30144-0 Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets multiple organs and causes severe coagulopathy. Histopathological organ changes might not only be attributable to a direct virus-induced effect, but also the immune response. The aims of this study were to assess the [...]
Categories: MATH+
Tags: COVID-19
Authors: Zhang Q, Bastard P, Liu Z, Le Pen J, Chen J, Korol C PMID: 32972995 PMCID: PMC7857407 DOI: 10.1126/science.abd4570 Abstract Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function [...]
Categories: MATH+
Tags: COVID-19
Authors: Kory P, Kanne JP PMID: 32963028 PMCID: PMC7509945 DOI: 10.1136/bmjresp-2020-000724 Abstract Reviews of COVID-19 CT imaging along with postmortem lung biopsies and autopsies indicate that the majority of patients with COVID-19 pulmonary involvement have secondary organising pneumonia (OP) or its histological variant, acute fibrinous and organising pneumonia, both well-known complications of viral infections. Further, [...]
Categories: MATH+
Tags: Pneumonia, SARS-CoV-2
Authors: Ruiz-Irastorza G, Pijoan JI, Bereciatua E, Dunder S, Dominguez J, Garcia-Escudero P PMID: 32960899 PMCID: PMC7508405 DOI: 10.1371/journal.pone.0239401 Abstract Objective: To analyze the effects of a short course of methyl-prednisolone pulses (MP) during the second week of disease (week-2) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia. Methods: Comparative observational study using data [...]
Categories: MATH+
Tags: COVID-19, Methylprednisolone
Coronavirus Disease 2019 (COVID-19) pandemic continues unabated in many parts of the world. In the absence of any definite antiviral therapy except some benefit of remdesivir, there is an ongoing search for effective therapy. Famotidine has been shown to reduce mortality in hospitalized patients in a few studies. We conducted a systematic review on the use of famotidine in COVID-19.
Categories: MATH+
Tags: Famotidine
Authors: Arvinte C, Singh M, Marik PE PMID: 32964205 PMCID: PMC7499070 DOI: 10.1016/j.medidd.2020.100064 Abstract Background: The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of [...]
Categories: MATH+