Categories
Tags
Authors: Keith P, Wells AH, Hodges J, Fast SH PMID: 32831133 PMCID: PMC7443810 DOI: 10.1186/s13054-020-03241-6 Abstract Background: Sepsis remains a common condition with high mortality when multiple organ failure develops. The evidence for therapeutic plasma exchange (TPE) in this setting is promising but inconclusive. Our study aims to evaluate the efficacy of adjunct TPE for [...]
Categories: MATH+
Authors: Mudatsir M, Yufika A, Nainu F, Frediansyah A, Megawati D doi: https://doi.org/10.3390/scipharm88030036 Abstract The coronavirus disease 2019 (COVID-19) pandemic is a major global threat. With no effective antiviral drugs, the repurposing of many currently available drugs has been considered. One such drug is ivermectin, an FDA-approved antiparasitic agent that has been shown to exhibit [...]
Categories: MATH+
Tags: COVID-19, ivermectin, SARS-CoV-2
Authors: Abrams D, Lorusso R, Vincent JL, Brodie D PMID: 32807189 PMCID: PMC7429936 DOI: 10.1186/s13054-020-03230-9 Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a critical shortage of resources in the hardest-hit areas around the world. Intensive care units (ICUs) overwhelmed by critically ill patients may create non-conventional ICU spaces and even consider triaging [...]
Categories: MATH+
Tags: COVID-19
Authors: de Melo AF, Homem-de-Mello M PMID: 32792018 PMCID: PMC7424130 DOI: 10.1186/s13054-020-03228-3 Abstract The complete mechanism of action of the SARS-CoV-2 remains unclear. The severity of the disease is probably linked to the “cytokine storm” that leads to the acute respiratory distress syndrome. Cytokine storm is an overwhelming increase of several inflammatory markers at once, [...]
Categories: MATH+
Authors: Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H PMID: 32783686 PMCID: PMC7429998 DOI: 10.7326/M20-3742 Abstract Background: Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)-associated outcomes, yet studies have not adequately disentangled their effects. Objective: To determine the adjusted effect of [...]
Categories: MATH+
Tags: COVID-19
Authors: De Flora S, Balansky R, La Maestra S PMID: 32780893 PMCID: PMC7436914 DOI: 10.1096/fj.202001807 Abstract COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has [...]
Categories: I-CARE Early Covid, I-RECOVER Long Covid, I-RECOVER Post-Vaccine, MATH+
Tags: COVID-19, N-Acetylcysteine
Authors: Marik PE, Stephenson E PMID: 32799183 DOI: 10.1016/j.jcrc.2020.07.026 Abstract Background: The global burden of death due to sepsis is considerable. Early diagnosis is essential to improve the outcome of this deadly syndrome. Yet, the diagnosis of sepsis is fraught with difficulties. Patients with blood stream infection (BSI) are at an increased risk of complications [...]
Categories: MATH+
Tags:
Authors: Gucyetmez B, Atalan HK, Sertdemir I, Cakir U, Telci L PMID: 32771054 PMCID: PMC7414262 DOI: 10.1186/s13054-020-03215-8 Abstract In patients with COVID-19 pneumonia, high risk of thrombosis became a current issue, and D-dimer levels indicating fibrin degradation products (FDPs) in the plasma were found as a predictor for mortality. Although unfractionated heparin (UFH) and low-molecular-weight [...]
Categories: I-RECOVER Post-Vaccine, MATH+
Authors: Pujadas E, Chaudhry F, McBride R, Richter F, Zhao S PMID: 32771081 PMCID: PMC7836878 DOI: 10.1016/S2213-2600(20)30354-4 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection platforms currently report qualitative results. However, technology based on RT-PCR allows for calculation of viral load, which is associated with transmission risk and disease severity in other viral illnesses.1 [...]
Categories: MATH+
Tags: COVID-19, SARS-CoV-2
Authors: Barrett TJ, Lee AH, Xia Y, Lin LH, Black M, Cotzia P PMID: 32757722 PMCID: PMC7478197 DOI: 10.1161/CIRCRESAHA.120.317803 Abstract The SARS-CoV-2 (SARS-CoV-2 severe acute respiratory syndrome coronavirus 2) coronavirus disease (COVID-19) is a global pandemic. Laboratory testing suggests a coagulopathy with up to 30% of hospitalized patients with COVID-19 developing thrombotic events.1 Platelets are [...]
Categories: MATH+
Tags: COVID-19, Thrombosis