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Authors: Liu J, Zheng X, Huang Y, Shan H, Huang J PMID: 32479759 PMCID: PMC7256545 DOI: 10.1016/j.jaci.2020.05.021 Abstract As of April 4, 2020, a total of 1,051,635 coronavirus disease 2019 (COVID-19) cases had been reported worldwide, among which 56,985 deaths occurred (5.42%).1 However, to date, no vaccine and no specific antiviral medicine are available to [...]
Categories: MATH+
Tags: COVID-19, Methylprednisolone
Authors: Cruz AF, Ruiz-Antoran B, Gomez AM, Lopez AS doi: https://doi.org/10.1101/2020.05.22.20110544 Abstract Objective We aim to determine the impact of steroid use in COVID-19 pneumonia in-hospital mortality. Design We performed a single-centre retrospective cohort study. Setting A University hospital in Madrid, Spain, during March 2020. Participants Patients admitted with SARS-CoV-2 pneumonia. Exposures Patients treated with [...]
Categories: MATH+
Tags: Glucocorticoids, SARS-CoV-2
Authors: Xu Q, Wang T, Quin X, Zha L PMID: 32448330 PMCID: PMC7246000 DOI: 10.1186/s13054-020-02991-7 Abstract Coronavirus disease 2019 (COVID-19) has rapidly spread around the world in the past 3 months and has now become a global public health crisis. The mortality of COVID-19 in some European cities exceeds 11%, and the fatality rate is [...]
Categories: MATH+
Tags: COVID-19
Authors: Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R et al. PMID: 33795830 PMCID: PMC8015313 DOI: 10.1038/s41379-021-00793-y Abstract BACKGROUND Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe, disproportionately affecting New York City. A comprehensive, integrative autopsy series that [...]
Categories: I-RECOVER Long Covid, MATH+
Tags: COVID-19, pathophysiology, SARS-CoV-2
Authors: Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T PMID: 32437596 PMCID: PMC7412750 DOI: 10.1056/NEJMoa2015432 Abstract Background: Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated [...]
Categories: MATH+
Tags: Angiogenesis, COVID-19, Endotheliitis, Thrombosis
Authors: Teuwen LA, Geldhof V, Pasut A, Carmeliet P PMID: 32439870 PMCID: PMC7240244 DOI: 10.1038/s41577-020-0343-0 Abstract On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection [...]
Categories: MATH+
Tags: COVID-19
Authors: George PM, Wells AU, Jenkins RG PMID: 32422178 PMCID: PMC7228727 DOI: 10.1016/S2213-2600(20)30225-3 Abstract In December, 2019, reports emerged from Wuhan, China, of a severe acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the end of April, 2020, over 3 million people had been confirmed infected, with over 1 million [...]
Categories: I-RECOVER Long Covid, MATH+
Tags: COVID-19, pulmonary fibrosis
Authors: Spagnolo P, Balestro E, Aliberti S, Cocconcelli E, Biondini D, Casa GD PMID: 32422177 PMCID: PMC7228737 DOI: 10.1016/S2213-2600(20)30222-8 Abstract As of May 6, 2020, nearly 3·7 million people have been infected and around 260 000 people have died from coronavirus disease 2019 (COVID-19) worldwide.1 Almost all COVID-19-related serious consequences feature pneumonia.2 In the first large [...]
Categories: I-RECOVER Long Covid, MATH+
Tags: COVID-19, pulmonary fibrosis
Authors: Chiumello D, Cressoni M, Gattinoni L PMID: 32228035 PMCID: PMC7233352 DOI: 10.1164/rccm.202003-0817LE Abstract In northern Italy, an overwhelming number of patients with coronavirus disease (COVID-19) pneumonia and acute respiratory failure have been admitted to our ICUs. Attention is primarily focused on increasing the number of beds, ventilators, and intensivists brought to bear on the [...]
Categories: MATH+
Authors: Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S PMID: 32416070 PMCID: PMC7227586 DOI: 10.1016/j.cell.2020.04.026 Abstract Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an [...]
Categories: MATH+
Tags: COVID-19, SARS-CoV-2