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Authors: Chroboczek T, Lacoste M, Wackenheim C, Challan-Belval T, Amar B, Boisson T doi: https://doi.org/10.1101/2020.05.08.20094755 Abstract Background Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for Coronavirus Disease 2019 (COVID-19), is spreading worldwide, causing significant morbidity and mortality. No specific treatment has yet clearly shown to improve the disease’s evolution. Validated therapeutic [...]
Categories: MATH+
Tags: Corticosteroids, COVID-19
Authors: Kurcicka L, Lauer SA, Laeyendecker O, Boon D, Lessler J PMID: 32422057 PMCID: PMC7240870 DOI: 10.7326/M20-1495 Abstract Background: Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse transcriptase polymerase chain reaction (RT-PCR) are being used to rule out infection among high-risk persons, such as exposed inpatients and health care workers. It [...]
Categories: MATH+
Tags: COVID-19, SARS-CoV-2
Authors: Banerjee A, Pasea L, Harris S, Gonzalez-Izquierdo A PMID: 32405103 PMCID: PMC7217641 DOI: 10.1016/S0140-6736(20)30854-0 Abstract Background: The medical, societal, and economic impact of the coronavirus disease 2019 (COVID-19) pandemic has unknown effects on overall population mortality. Previous models of population mortality are based on death over days among infected people, nearly all of whom [...]
Categories: MATH+
Tags: COVID-19
Authors: Wang J, Najizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA PMID: 32267998 PMCID: PMC7262152 DOI: 10.1111/jth.14828 Abstract A prothrombotic coagulopathy is commonly found in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). A unique feature of COVID-19 respiratory failure is a relatively preserved lung compliance and high Alveolar-arterial oxygen gradient, [...]
Categories: MATH+
Authors: Spinelli FR, Conti F, Gadina M PMID: 32385052 DOI: 10.1126/sciimmunol.abc5367 Abstract JAK kinase inhibitors are being investigated as a way of managing cytokine storm in severe COVID-19 patients. Keywords: SARS-CoV-2, JAK inhibitors, COVID-19 Source: https://pubmed.ncbi.nlm.nih.gov/32385052/ Archive: https://archive.ph/Jwcrd
Categories: MATH+
Tags: COVID-19, SARS-CoV-2
Authors: Dayer MR doi: 10.20944/preprints202005.0020.v1 Abstract The disease of COVID-19 comprises the most serious against human health worldwide with a high rate of virulence and mortality. The disease is caused by the 2019-nCoV virus from the beta coronavirus family. The virus makes use of its surface glycoprotein named S protein or spike to enter the [...]
Categories: I-CARE Early Covid, MATH+
Tags: COVID-19, Spike Protein
Authors: Patel AN, Desai SS, Grainger DW, Mehra MR Abstract Importance: There is no established anti-viral therapy for treating COVID-19 illness. Objective: To study the usefulness of Ivermectin, an antimicrobial therapy, in COVID-19 outcomes. Design: An international, multicenter, observational propensity-score matched case-controlled study using prospectively collected data on patients diagnosed with [...]
Categories: MATH+
Tags: COVID-19, ivermectin
Authors: Rothlin RP, Vetulli HM, Duarte M, Pelorosso FG PMID: 32356926 PMCID: PMC7267340 DOI: 10.1002/ddr.21679 Abstract In late 2019, a new coronavirus emerged in Wuhan Province, China, causing lung complications similar to those produced by the SARS coronavirus in the 2002-2003 epidemic. This new disease was named COVID-19 and the causative virus SARS-CoV-2. The SARS-CoV-2 [...]
Categories: MATH+
Tags: COVID-19, telmisartan
Authors: Villar J, Confalonieri M, Pastores SM, Meduri GU PMID: 32426753 PMCID: PMC7188431 DOI: 10.1097/CCE.0000000000000111 Abstract In December 2019, pneumonia associated with the novel coronavirus disease 2019 (COVID-19) emerged in Wuhan, China. On March 14, 2020, the World Health Organization (WHO) declared the coronavirus outbreak a pandemic with confirmed cases in 127 countries. This unprecedented [...]
Categories: MATH+
Authors: Leisman DE, Deutschman CS, Legrand M PMID: 32347323 PMCID: PMC7186535 DOI: 10.1007/s00134-020-06059-6 Abstract Current management guidelines for COVID-19 reflect the assumption that critically ill patients infected with SARS-CoV-2 develop acute respiratory distress syndrome (ARDS). However, emerging data and clinical reports increasingly suggest an alternative view that severe COVID-19 reflects a confluence of vascular dysfunction, [...]
Categories: MATH+