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Authors: Li MY, Li L, Zhang Y, Wang XS PMID: 32345362 PMCID: PMC7186534 DOI: 10.1186/s40249-020-00662-x Abstract Background: Since its discovery in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has caused more than 150 000 deaths as of April 16, 2020. SARS-CoV-2, which is [...]
Categories: MATH+
Tags: ACE2 protein, SARS-CoV-2
Authors: Tay MZ, Poh CM, Renia L, MacAry PA PMID: 32346093 PMCID: PMC7187672 DOI: 10.1038/s41577-020-0311-8 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 [...]
Categories: MATH+
Tags: COVID-19, Immunity, Inflammation
Authors: Tan C, Huang Y, Shi F, Tan K, Ma Q, Chen Y PMID: 32281668 PMCID: PMC7262341 DOI: 10.1002/jmv.25871 Abstract COVID-19 has developed into a worldwide pandemic; early identification of severe illness is critical for controlling it and improving the prognosis of patients with limited medical resources. The present study aimed to analyze the characteristics [...]
Categories: MATH+
Tags: COVID-19
Authors: Copin MC, Parmentier E, Duburcq T, Poissy J, Mathieu D PMID: 32328726 PMCID: PMC7178098 DOI: 10.1007/s00134-020-06057-8 Abstract In their editorial about ‘COVID-19 pneumonia: different respiratory treatment for different phenotypes’ Gattinoni et al. hypothesize a sequence of events in critically ill patients infected by SARS-CoV-2. They describe a type L characterized by a low elastance, [...]
Categories: MATH+
Tags: COVID-19
Authors: Goren A, Vamo-Galvan S, Wambier CG, McCoy J PMID: 32301221 DOI: 10.1111/jocd.13443 Abstract A preliminary observation of high frequency of male pattern hair loss among admitted COVID-19 patients and suggest that androgen expression might be a clue to COVID-19 severity. Keywords: 5-alpha reductase; ACE2; SARS-CoV-2; TMPRSS2; androgenetic alopecia. Source: https://pubmed.ncbi.nlm.nih.gov/32301221/ Archive: https://archive.ph/BBGXS [...]
Categories: MATH+
Authors: Varga Z, Flammer AJ, Steiger P, Habrecker M, Andermatt R, Zinkernagel AS PMID: 32325026 PMCID: PMC7172722 DOI: 10.1016/S0140-6736(20)30937-5 Abstract Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease 2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the disproportionate effect of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection on patients [...]
Categories: MATH+
Tags: COVID-19, Endotheliitis
Authors: Boretti A, Banik BK PMID: 32322486 PMCID: PMC7172861 DOI: 10.1016/j.phanu.2020.100190 Abstract The recent outbreak of Covid19 has required urgent treatments for numerous patients. No suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of WHO therapies of choice, that are two antivirals developed for other pathologies, is controversial. Therefore, alternative approaches [...]
Categories: MATH+
Authors: Giamarellos-Bouboulis EJ, Netea MG, Rovina N, Akinosoglou K, Antoniadou A, Antonakos N et al. PMID: 32320677 PMCID: PMC7172841 DOI: 10.1016/j.chom.2020.04.009 Abstract Proper management of COVID-19 mandates better understanding of disease pathogenesis. The sudden clinical deterioration 7-8 days after initial symptom onset suggests that severe respiratory failure (SRF) in COVID-19 is driven by a unique [...]
Categories: MATH+
Tags: COVID-19, respiratory failure
Authors: Ding X, Xu J, Zhou J, Long Q PMID: 32325282 PMCID: PMC7165099 DOI: 10.1016/j.ejrad.2020.109009 Abstract Purpose: To evaluate lung abnormalities on thin-section computed tomographic (CT) scans in patients with COVID-19 and correlate findings to duration of symptoms. Methods: In total, 348 CT scans in 112 patients were classified according to the time after the [...]
Categories: MATH+
Authors: Moore JB, June CH PMID: 32303591 DOI: 10.1126/science.abb8925 Abstract In December 2019, a new strain of coronavirus, severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China. Along with SARS-CoV and Middle East respiratory syndrome–coronavirus (MERS-CoV), SARS-CoV-2 is the third coronavirus to cause severe respiratory illness in humans, called coronavirus [...]
Categories: MATH+