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Authors: Gattinoni L, Chiumello D, Rossi S PMID: 32299472 PMCID: PMC7160817 DOI: 10.1186/s13054-020-02880-z Abstract Even though it can meet the ARDS Berlin definition, the COVID-19 pneumonia is a specific disease with peculiar phenotypes. Its main characteristic is the dissociation between the severity of the hypoxemia and the maintenance of relatively good respiratory mechanics. Indeed, the [...]
Categories: MATH+
Authors: Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L PMID: 32291463 PMCID: PMC7154064 DOI: 10.1007/s00134-020-06033-2 Abstract The Surviving Sepsis Campaign panel recently recommended that “mechanically ventilated patients with COVID-19 should be managed similarly to other patients with acute respiratory failure in the ICU.” Yet, COVID-19 pneumonia, despite falling in most of [...]
Categories: MATH+
Authors: Ye Q, Wang B, Mao J PMID: 32283152 PMCID: PMC7194613 DOI: 10.1016/j.jinf.2020.03.037 Abstract Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration [...]
Categories: MATH+
Authors: Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. PMID: 32251768 PMCID: PMC7129059 DOI: 10.1016/j.antiviral.2020.104787 Abstract Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum [...]
Categories: I-CARE Early Covid, MATH+
Tags: ivermectin, SARS-CoV-2
Authors: McGonagle D, Sharif K, O'Regan A, Bridgewood C PMID: 32251717 PMCID: PMC7195002 DOI: 10.1016/j.autrev.2020.102537 Abstract Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-inflammation designated under the umbrella term of macrophage activation syndrome (MAS) or cytokine storm, also known as secondary haemophagocytic lymphohistocytosis (sHLH). This is distinct from HLH associated with immunodeficiency [...]
Categories: MATH+
Authors: Keith P, Day M, Perkins L, Moyer L, Hewitt K, Wells A PMID: 32241301 PMCID: PMC7117947 DOI: 10.1186/s13054-020-2836-4 Abstract The novel coronavirus (“SARS-CoV-2”) outbreak has created a sense of panic globally and has the medical community rapidly searching for answers. An estimated 100,000 individuals have already been infected with nearly 3300 deaths attributed to [...]
Categories: I-RECOVER Post-Vaccine, MATH+
Authors: Henry MB, Lippi G PMID: 32279018 PMCID: PMC7118619 DOI: 10.1016/j.jcrc.2020.03.011 Abstract The novel coronavirus disease 2019 (COVID-19) can induce acute respiratory distress syndrome (ARDS), which can progress to refractory pulmonary failure. In such cases, extracorporeal membrane oxygenation (ECMO) may be considered as a rescue therapy. In a study of ECMO for ARDS in patients [...]
Categories: MATH+
Authors: Yang R, Li X, Liu H, Zhen Y, Zhang X, Xiong Q et al. PMID: 33778560 PMCID: PMC7233443 DOI: 10.1148/ryct.2020200047 Abstract Purpose: To evaluate the value of chest CT severity score (CT-SS) in differentiating clinical forms of coronavirus disease 2019 (COVID-19). Materials and methods: A total of 102 patients with COVID-19 confirmed by a [...]
Categories: MATH+
Authors: Zhang C, Wu Z, Li JW, Zhao H, Wang GQ PMID: 32234467 PMCID: PMC7118634 DOI: 10.1016/j.ijantimicag.2020.105954 Abstract Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19), from Wuhan, China, has swept the world. Although the case fatality rate is not high, the number of people infected is large and there is still [...]
Categories: MATH+
Authors: Cheng RZ PMID: 32328576 PMCID: PMC7167497 DOI: 10.1016/j.medidd.2020.100028 Abstract The COVID-19 (SARS-2-Cov) pandemic, first reported in Wuhan, China, is now spreading to many continents and countries, causing a severe public health burden. Currently, there is no vaccine or specific antiviral drug for this deadly disease. A quick, deployable and accessible, effective and safe treatment [...]
Categories: MATH+