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Authors: Skurikhin EG, Andreeva TV, Khnelevskaya ES, Ermolaeva LA, Pershina OV, Krupin VA PMID: 22803125 DOI: 10.1007/s10517-012-1567-1 Abstract The effects of antiserotonin preparation on the development of the connective tissue in the lungs, reaction of the blood system, and the content of hemopoietic stem cells, committed hemopoietic and stromal precursors in BM, spleen, and peripheral [...]
Categories: MATH+
Tags: bleomycin, Lung Fibrosis
Authors: Ichikado K, Muranaka H, Gushima Y, Kotani T, Nader HM, Fujimoto K et al. PMID: 22382117 PMCID: PMC3293132 DOI: 10.1136/bmjopen-2011-000545 Abstract Objectives: To examine whether the extent of fibroproliferative changes on high-resolution CT (HRCT) scan influences prognosis, ventilator dependency and the associated outcomes in patients with early acute respiratory distress [...]
Categories: MATH+
Authors: Lee CY, Jan WC, Tsai PS, Huang CJ PMID: 21610432 DOI: 10.1097/TA.0b013e31820ca695 Abstract Background: Magnesium sulfate (MgSO4) possesses potent anti-inflammation capacity. We sought to elucidate the effects of MgSO4 on mitigating acute lung injury induced by endotoxemia. MgSO4 is an antagonist of the L-type calcium channels and the N-methyl-D-aspartate (NMDA) receptor. The roles of [...]
Categories: MATH+
Tags: Acute Lung Injury, Magnesium
Oxidative stress acutely increases the permeability of the vascular endothelium to large molecules that would not otherwise cross the barrier. Ascorbic acid is an antioxidant that tightens the endothelial permeability barrier, so we tested whether it might also prevent the increase in endothelial permeability due to cellular oxidative stress.
Categories: MATH+
Authors: Cerutti A, Chen K, Chorny A PMID: 21219173 PMCID: PMC3064559 DOI: 10.1146/annurev-immunol-031210-101317 Abstract Mucosal surfaces are colonized by large communities of commensal bacteria and represent the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B cells release large amounts of immunoglobulin (Ig) molecules through multiple follicular and extrafollicular pathways. IgA [...]
Categories: MATH+
Tags: Immunoglobulin
Authors: May JM, Qu ZC PMID: 21328627 PMCID: PMC3725122 DOI: 10.1002/biof.134 Abstract Oxidative stress acutely increases the permeability of the vascular endothelium to large molecules that would not otherwise cross the barrier. Ascorbic acid is an antioxidant that tightens the endothelial permeability barrier, so we tested whether it might also prevent the increase in endothelial [...]
Categories: MATH+
Tags: Ascorbic Acid
Authors: Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Pollak U PMID: 20586571 DOI: 10.3109/15563650.2010.495348 Abstract Introduction: Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, MATH+
Tags: colchicine
Authors: Han M, Pendem S, Teh SL, Sukumaran DK, Wu F, Wilson JX PMID: 19840845 PMCID: PMC2818310 DOI: 10.1016/j.freeradbiomed.2009.10.034 Abstract Endothelial barrier dysfunction contributes to morbidity in sepsis. We tested the hypothesis that raising the intracellular ascorbate concentration protects the endothelial barrier from septic insult by inhibiting protein phosphatase type 2A. Monolayer cultures of microvascular [...]
Categories: MATH+
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Authors: Chen L, Jiang X, Huang L, Lan K, Wang H, Hu L et al. PMID: 19922895 DOI: 10.1016/j.clinthera.2009.09.015 Abstract Background: Finasteride, an inhibitor of the steroid 5alpha-reductase, has been approved for the treatment of benign prostatic hyperplasia and androgenetic alopecia. An orally disintegrating tablet (ODT) 5-mg formulation of finasteride was recently developed. Information regarding [...]
Categories: MATH+
Tags: Finasteride
Authors: Ci X, Li H, Yu Q, Zhang X, Yu L, Chen N et al. PMID: 19453757 DOI: 10.1111/j.1472-8206.2009.00684.x Abstract Lipopolysaccharide (LPS) can induce mouse macrophages to produce a number of cytokines and other inflammatory mediators. Immunopharmacological studies can provide new information on the immunomodulatory activities of some drugs, including their effect on cytokine productions. [...]
Categories: I-RECOVER Post-Vaccine, MATH+
Tags: Anti-inflammatory, Avermectin