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Authors: MacLean MR, Herve P, Eddahibi S, Adnot S PMID: 10991906 PMCID: PMC1572323 DOI: 10.1038/sj.bjp.0703570 Abstract Circulating 5-hydroxytryptamine (5-HT) is produced mainly in the enterochromaffin cells of the intestine. 5-HT is also, however, locally released from pulmonary neuroendocrine cells and neuroepithelial bodies distributed throughout the airways. Secretion of large amounts of 5-HT from these cells [...]
Categories: MATH+
Tags: Pulmonary Circulation
Authors: Utoguchi N, Ikeda K, Saeki K, Oka N, Mizuguchi H, Kubo K et al. PMID: 7706381 DOI: 10.1002/jcp.1041630219 Abstract The macromolecular permeability of cultured bovine aortic, bovine venous, and human umbilical vein endothelial cell monolayers was decreased significantly in culture medium containing L-ascorbic acid (Asc Acid; 0.01-0.1 mM) and L-ascorbic acid 2-phosphate (Asc 2-P). [...]
Categories: MATH+
Tags: Ascorbic Acid
Authors: Salem M, Kasinski N, Munoz R, Chernow B PMID: 8001362 DOI: 10.1097/00003246-199501000-00019 Abstract Objectives: To study the effects of endotoxin on magnesium homeostasis; to determine if progressive magnesium deficiency alters outcome from endotoxin challenge; and to evaluate the efficacy of magnesium therapy in reducing endotoxin-induced mortality. Design: Prospective, placebo-controlled, randomized, multiexperiment studies. Setting: Research [...]
Categories: MATH+
Tags: Magnesium
Authors: Blackshear JL, Orlandi C, Hollenberg NK PMID: 1708058 DOI: 10.1097/00005344-199101000-00010 Abstract Serotonin (5HT) has been implicated in the pathogenesis of several arterial disorders. Experimental intrarenal infusion of 5HT has produced initial decreases, and later sustained increases in total renal blood flow in the dog, and flow limiting renal artery spasm in other species. We [...]
Categories: MATH+
Tags: Serotonin
Authors: Dawson C, Christensen CW, Rickaby DA, Linehan JH, Johnston MR PMID: 2409068 DOI: 10.1152/jappl.1985.58.6.1761 Abstract We examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of [3H]serotonin and the extravascular volume accessible to [14C]antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin [...]
Categories: MATH+
Tags: Serotonin
Authors: Almqvist P, Skudder P, Kuenzig M, Schwartz SI PMID: 6476613 Abstract The adult respiratory distress syndrome (ARDS) seen in endotoxin shock is accompanied by the release of beta-endorphin. The hypotension that is seen in endotoxin shock can also be produced by injection of beta-endorphin and is effectively blocked by the use of antiserotonin drugs. [...]
Categories: MATH+
Authors: McGoon MD, Vanhoutte PM PMID: 6470141 PMCID: PMC425237 DOI: 10.1172/JCI111499 Abstract To examine the effect of platelets and 5-hydroxytryptamine on pulmonary arterial smooth muscle, rings of canine pulmonary arteries, with and without endothelium, were studied under isometric conditions in physiological salt solution. 5-Hydroxytryptamine, but not the thromboxane-like endoperoxide analogue U-46619, produced concentration-dependent contractions of [...]
Categories: MATH+
Tags: pulm
To compare the penetrability of methylprednisolone into lung tissue with that of prednisone, blood and bronchoalveolar lavage (BAL) fluid levels of methylprednisolone and prednisone were measured in 17 patients with a variety of lung diseases.
Categories: MATH+
Tags: Methylprednisol, Prednisone