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Authors: Supady A, Taccone FS, Lepper PM, Ziegeler S, Staudacher DL PMID: 33648538 PMCID: PMC7919616 DOI: 10.1186/s13054-021-03486-9 Abstract Survival of coronavirus disease 2019 (COVID-19) patients with severe respiratory failure treated with veno-venous extracorporeal membrane oxygenation (V-V ECMO) ranges around 60%, according to recent studies. Initial recommendations for the use of V-V [...]
Categories: MATH+
Authors: Gordon AC, Mouncey PR, Rowan KM, Nichol AD, Arabi YM, Annane D PMID: 33631065 PMCID: PMC7953461 DOI: 10.1056/NEJMoa2100433 Abstract Background: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. Methods: We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with [...]
Categories: MATH+
Tags: COVID-19
Authors: Rosas IO, Brau N, Waters M, Go R, Hunter BD, Bhagani S et al. PMID: 33631066 PMCID: PMC7953459 DOI: 10.1056/NEJMoa2028700 Abstract Background: Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better outcomes in [...]
Categories: MATH+
Tags: COVID-19, Tocilizumab
Authors: Ko JJ, Wu C, Mehta N, Wald-Dickler N, Yang W PMID: 33632000 DOI: 10.1177/0885066621994057 Abstract Objectives: This study retrospectively compares the effectiveness of methylprednisolone to dexamethasone in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) requiring intensive care. Design: This is an institutional review board approved cohort study in patients with [...]
Categories: MATH+
Tags: COVID-19, dexamethasone, Methylprednisolone
Authors: Simonovich VA, Pratx LD, Scibona P, Beruto MV, Vallone MG DOI: 10.1056/NEJMoa2031304 Abstract BACKGROUND Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered randomized, controlled trials. METHODS We randomly assigned hospitalized adult [...]
Categories: MATH+
Tags: COVID-19
Authors: Al Sulaiman K, Al Juhani O, Badreldin HA, Salah KB, Alharbi A, Arabi YM doi: https://doi.org/10.21203/rs.3.rs-227158/v1 Abstract Background: Due to its supposed clinical efficacy, relative safety, and low cost, ascorbic acid represents an appealing option for clinicians to utilize in the context of a global health pandemic of COVID-19 patients. Objectives: The aim of [...]
Categories: MATH+
Tags: Ascorbic Acid, COVID-19
Previous reports have found that in-hospital famotidine use in coronavirus disease 2019 (COVID-19) patients was associated with reduced risk of death or intubation.1 , 2 In 1 of these studies the authors proposed that famotidine inhibits the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease, 3-chymotrypsin-like protease, that is essential for breakdown of the immature SARS-CoV-2 protein particles that contribute to the inflammatory response seen in some COVID-19–infected individuals,1 which in turn can lead to acute respiratory distress syndrome, multiorgan dysfunction, physiologic deterioration, and death.3 In a global pandemic with a lack of US Food and Drug Administration–approved targeted therapeutic agents, identification and repurposing of well-established drugs with a proven track record of safety, affordability, and widespread availability are necessary.4 The purpose of this study was to evaluate the reported protective effect of famotidine on mortality in hospitalized COVID-19 patients.
Categories: MATH+
Tags: Famotidine
Authors: Thompson MA, Henderson JP, Shah PK, Rubenstein SM, Joyner MJ, Flora DB. doi: https://doi.org/10.1101/2021.02.05.21250953 Abstract Convalescent plasma may benefit immunocompromised individuals with COVID-19, including those with hematologic malignancy. We evaluated the association of convalescent plasma treatment with 30-day mortality in hospitalized adults with hematologic malignancy and COVID-19 from a multi-institutional cohort. 143 treated patients [...]
Categories: MATH+
Tags: Convalescent Plasma, COVID-19
Authors: Cadegiani FA, McCoy J, Wambier CG, Goren A PMID: 33643746 PMCID: PMC7885746 DOI: 10.7759/cureus.13047 Abstract Background and objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and subsequent infectivity are mediated by androgens and the androgen receptors through the regulation of transmembrane protease, serine 2 (TMPRSS2). Androgenetic alopecia (AGA) [...]
Categories: I-CARE Early Covid, MATH+
Tags: Antiandrogen Therapy, COVID-19
Authors: Sweeney TE, Liesenfeld O, Wacker J, He YD, rawling D, Remmel M PMID: 33201004 DOI: 10.1097/CCM.0000000000004786 AbstractObjectives: Complex critical syndromes like sepsis and coronavirus disease 2019 may be composed of underling "endotypes," which may respond differently to treatment. The aim of this study was to test whether a previously defined bacterial sepsis endotypes classifier [...]
Categories: MATH+