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Authors: Patterson G, Isales CM, Fulzele S PMID: 33532123 PMCID: PMC7801272 DOI: 10.14336/AD.2020.0918 Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been spreading around the world at an exponential pace, leading to millions of individuals developing the associated disease called COVID-19. Due to the novel nature and the lack of immunity within humans, [...]
Categories: MATH+
Authors: Lankadeva YR, Peiris RM, Okazaki N, Birchall IE, Doenom A, Evans RG et al. PMID: 33239507 PMCID: PMC7803449 DOI: 10.1097/CCM.0000000000004770 Abstract Objectives: Oxidative stress appears to initiate organ failure in sepsis, justifying treatment with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety and efficacy of megadose sodium ascorbate in [...]
Categories: MATH+
Authors: Caplan M, Goutay J, Bignon A, Jaillette E, Favory R PMID: 33093279 DOI: 10.1097/CCM.0000000000004711 Abstract Objectives: Treating acute respiratory failure in patients with coronavirus disease 2019 is challenging due to the lack of knowledge of the underlying pathophysiology. Hypoxemia may be explained in part by the loss of hypoxic pulmonary vasoconstriction. The present study [...]
Categories: MATH+
Authors: Zaid Y, Guessous F, Puhm F, Elhamdani W, Chentoufi L, Morris AC PMID: 33560374 PMCID: PMC7846461 DOI: 10.1182/bloodadvances.2020003513 Abstract In addition to preserving homeostasis and contributing to immunity, platelets may exhibit a dysregulated state, in acute respiratory distress syndrome (ARDS) and potentially exacerbate lung injury.Although thrombocytopenia has been associated with increased mortality in ARDS,and [...]
Categories: MATH+
Authors: Zhang J, Rao X, Li Y, Zhu Y, Liu G, Guo G et al. PMID: 33420963 PMCID: PMC7794643 DOI: 10.1186/s13613-020-00792-3 Abstract Background: Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe COVID-19. Methods: [...]
Categories: MATH+
Authors: Salvarani C, Dolci G, Massari M, Merlo DF, Cavuto S PMID: 33080005 PMCID: PMC7577199 DOI: 10.1001/jamainternmed.2020.6615 Abstract Importance: The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile. Objective: To evaluate the effect of [...]
Categories: MATH+
Tags: COVID-19, Tocilizumab
Authors: Hermine O, Mariette X, Tharaux PL, Resche-Rignon M, Porcher R PMID: 33080017 PMCID: PMC7577198 DOI: 10.1001/jamainternmed.2020.6820 Abstract Importance: Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). Objective: To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia. Design, setting, and particpants: This [...]
Categories: MATH+
Tags: COVID-19, Pneumonia, Tocilizumab
Khan MS, Khan MS, Debnath Cr et al. PMID: 33293006 PMCID: PMC7837160 DOI: 10.1016/j.arbres.2020.08.007 Abstract No abstract available Keywords: ivermectin Source: https://pubmed.ncbi.nlm.nih.gov/34629660/ Archive: https://archive.is/wip/67u8W
Categories: MATH+
Tags: ivermectin
Authors: Edalatifard M, Akhtari M, Salehi M, Naderi Z, Jamshidi A, Mostafaei S PMID: 32943404 PMCID: PMC7758541 DOI: 10.1183/13993003.02808-2020 Abstract Introduction: There are no determined treatment agents for severe COVID-19. It is suggested that methylprednisolone, as an immunosuppressive treatment, can reduce the inflammation of the respiratory system in COVID-19 patients. Methods: [...]
Categories: MATH+
Tags: COVID-19, Methylprednisolone
Authors: Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, et al. PMID: 33356051 PMCID: PMC7781100 DOI: 10.1056/NEJMoa2033130 Abstract Background: LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on [...]
Categories: MATH+
Tags: COVID-19