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Authors: Ahmad Q, DePerrior SE, Dodani S, Edwards JF, Marik PE DOI: https://doi.org/10.18103/mra.v8i12.2307 Abstract Background: Inflammatory cytokines have been implicated in the pathophysiology and prognosis of severe COVID-19. Inflammatory biomarkers may guide the clinician in making treatment decisions as well as in the allocation of resources. Objective: This study aimed to assess how levels of [...]
Categories: MATH+
Tags: COVID-19
Authors: Salama C, Han J, Yau L, Reiss WG, Kramer B PMID: 33332779 PMCID: PMC7781101 DOI: 10.1056/NEJMoa2030340 Abstract Background: Coronavirus disease 2019 (Covid-19) pneumonia is often associated with hyperinflammation. Despite the disproportionate incidence of Covid-19 among underserved and racial and ethnic minority populations, the safety and efficacy of the anti-interleukin-6 receptor antibody tocilizumab in patients [...]
Categories: MATH+
Tags: COVID-19, Tocilizumab
Authors: Koehler P, Bassetti M, Chen SC, Colombo AL, Perfect JR PMID: 33333012 PMCID: PMC7833078 DOI: 10.1016/S1473-3099(20)30847-1 Abstract Severe acute respiratory syndrome coronavirus 2 causes direct damage to the airway epithelium, enabling aspergillus invasion. Reports of COVID-19-associated pulmonary aspergillosis have raised concerns about it worsening the disease course of COVID-19 and increasing mortality. Additionally, the [...]
Categories: MATH+
Tags: COVID-19, Pulmonary Aspergillosis
Authors: Kalfas S, Visvanathan K, Chan K, Drago J. doi: https://doi.org/10.1101/2020.11.30.20236570 Abstract Introduction Ivermectin is a commonly used antihelminthic agent with over 35 years of established safety data in humans. Recent data demonstrates antiviral activity in vitro against SARS-CoV-2, in addition to a range of viruses. In vitro and animal models also provide evidence of [...]
Categories: MATH+
Tags: COVID-19, ivermectin
Authors: Fatima S, Zaidi SS, Alsharidah AS, Alijaser FS, Banu N PMID: 33344529 PMCID: PMC7744567 DOI: 10.3389/fvets.2020.585789 Abstract SARS-CoV-2, an epidemic, causes severe stress in both human and animals and may induce oxidative stress (OS) and increases susceptibility to infection. Domestic animals are found infected by their COVID-2 suffering owners. Chronic immobilization stress (CIS), a [...]
Categories: MATH+
Tags: Melatonin, SARS-CoV-2, Vitamin C, Zinc
Authors: Fernandez J, Gratacos-Gines J, Olivas P, Costa M, Nieto S, Mateo D PMID: 32833695 PMCID: PMC7493773 DOI: 10.1097/CCM.0000000000004613 Abstract Objectives: Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can [...]
Categories: I-RECOVER Post-Vaccine, MATH+
Authors: Kumari P, Dembra S, Dembra P, Bhawna F, Gul A, Ali B PMID: 33409026 PMCID: PMC7779177 DOI: 10.7759/cureus.11779 Abstract Background and objective The anti-inflammatory properties of vitamin C (VC) and the promising results it has shown in the treatment for common cold have prompted clinicians to use it as adjuvant [...]
Categories: MATH+
Authors: Peralta EG, Fimia-Duarte R, Cardenas JW, Dominguez DV, Segura RB Abstract Covid-19 is one of the viral infections that have always accompanied us. In some years harmless, but from time to time with a higher risk potential. What is particularly unsettling for us is that transmission often occurs from a [...]
Categories: MATH+
Tags: COVID-19, ivermectin, SARS-CoV-2
Authors: Fadel R, Morrison AR, Vahia A, Smith ZR, Chaudry Z, Bhargava P et al. PMID: 32427279 PMCID: PMC7314133 DOI: 10.1093/cid/ciaa601 Abstract Background: There is no proven antiviral or immunomodulatory therapy for coronavirus disease 2019 (COVID-19). The disease progression associated with the proinflammatory host response prompted us to examine the role of early corticosteroid therapy [...]
Categories: MATH+
Tags: Corticosteroids, COVID-19
Authors: Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF. doi: https://doi.org/10.1101/2020.11.16.20232397 Abstract Importance Patients with COVID-19 may exhibit 25-hydroxyvitamin D deficiency, but the beneficial effects of vitamin D3 supplementation in this disease remain to be proven by randomized controlled trials. Objective To investigate the efficacy and safety of vitamin D3 supplementation in patients [...]
Categories: I-CARE Early Covid, I-PREVENT, MATH+