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Auhtors: Huang W, Sundquist J, Sundquist K, Ji J PMID: 31103628 DOI: 10.1053/j.gastro.2019.05.012 Abstract Background & aims: Phosphodiesterase 5 (PDE5) inhibitors have been proposed to have chemopreventative effects on colorectal cancer (CRC), although data are needed from population-based studies. We performed a nationwide cohort study to investigate the association between the use of PDE5 inhibitors [...]
Categories: Cancer Care
Tags: Colon Cancer
Auhtors: Chandrasekaran B, Pal D, Kolluru V, Tyagi A, Baby B, Dahiya NR, et al. PMID: 30124785 PMCID: PMC6314334 DOI: 10.1093/carcin/bgy109 Abstract Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of WA on transgenic adenomatous polyposis coli (APCMin/+) mouse and chemically induced [...]
Categories: Cancer Care
Tags: Colon Cancer
Auhtors: Medema JP PMID: 28854096 DOI: 10.1056/NEJMcibr1706541 Abstract Two recent studies in mice show that, on ablation of colon cancer stem cells, differentiated cancer cells can dedifferentiate to supply a new pool of cancer stem cells, and extracellular signals have a role in this process. Keywords: colorectal cancer, stem cell Source: https://pubmed.ncbi.nlm.nih.gov/28854096/ Archive: https://archive.is/UgkLh [...]
Categories: Cancer Care
Tags: Colon Cancer
Auhtors: Williamson T, Bai RY, Staedtke V, Huso D, Riggins GJ PMID: 27612418 PMCID: PMC5356574 DOI: 10.18632/oncotarget.11851 Abstract Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed a chemoprevention strategy using a novel combination of the non-steroidal anti-inflammatory (NSAID) sulindac plus the [...]
Categories: Cancer Care
Tags: Anti-inflammatory, Colon Cancer, Tumor
Auhtors: Meyerhardt JA, Sato K, Niedzwiecki D, Ye C, Saltz LB, Mayer RJ, et al. PMID: 23136358 PMCID: PMC3502194 DOI: 10.1093/jnci/djs399 Abstract Background: The influence of glycemic load and related measures on survival among colon cancer patients remains largely unknown. Methods: We conducted a prospective, observational study of 1011 stage III colon cancer patients reporting [...]
Categories: Cancer Care
Tags: Colon Cancer, Glycemic Load
Auhtors: Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C PMID: 20053782 PMCID: PMC3041017 DOI: 10.1158/1535-7163.MCT-09-0771 Abstract Notch signaling plays a crucial role in the development of colon cancer; targeting the Notch pathway may sensitize colon cancers to various adjuvant agents. The focus of our current study is to identify natural compounds that target [...]
Categories: Cancer Care
Tags: Colon Cancer