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Auhtors: Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, et al. Abstract Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective therapy for decades. Although glucose and glutamine are the major fuels that drive GBM growth and invasion, few studies have targeted these fuels for therapeutic management. [...]
Categories: Cancer Care
Tags: Glioblastoma, Keto Diet
Auhtors: Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, et al. PMID: 28720668 DOI: 10.1158/1078-0432.CCR-16-3102 Abstract Purpose: Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractive therapeutic target in cancer; [...]
Categories: Cancer Care
Tags: Glioblastoma, Metabolism
Auhtors: Yang C, Sudderth J, Dang T, Bachoo RG, McDonald JG, Deberardinis RJ PMID: 19826036 PMCID: PMC2764330 DOI: 10.1158/0008-5472.CAN-09-2266 Abstract Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamine addiction"), suggesting that treatments targeting glutamine metabolism might selectively kill c-Myc-transformed tumor [...]
Categories: Cancer Care
Tags: Glioblastoma, Glucose Metabolism