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Auhtors: Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, et al. PMID: 29657030 PMCID: PMC5932217 DOI: 10.1016/j.cmet.2018.03.002 Abstract Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated [...]
Categories: Cancer Care
Tags: Glutamine, Metabolism