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Authors: Draghici S, Nguyen TM, Sonna LA, Ziraldo C, Vanciu R, Fadel R et al. PMID: 33693506 PMCID: PMC7989618 DOI: 10.1093/bioinformatics/btab163 Abstract Motivation: COVID-19 has several distinct clinical phases: a viral replication phase, an inflammatory phase and in some patients, a hyper-inflammatory phase. High mortality is associated with patients developing cytokine storm syndrome. Treatment of [...]
Categories: I-CARE Early Covid, MATH+
Tags: COVID-19, Methylprednisolone
Authors: Ranjbar K, Shahriarad R, erfani A, Khodamoradi Z, Saadi MH PMID: 33838657 PMCID: PMC8035859 DOI: 10.1186/s12879-021-06045-3 Abstract Background: Although almost a year has passed since the Coronavirus disease 2019 (COVID-19) outbreak and promising reports of vaccines have been presented, we still have a long way until these measures are available for all. Furthermore, the [...]
Categories: MATH+
Authors: Ko JJ, Wu C, Mehta N, Wald-Dickler N, Yang W PMID: 33632000 DOI: 10.1177/0885066621994057 Abstract Objectives: This study retrospectively compares the effectiveness of methylprednisolone to dexamethasone in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) requiring intensive care. Design: This is an institutional review board approved cohort study in patients with [...]
Categories: MATH+
Tags: COVID-19, dexamethasone, Methylprednisolone
Authors: Edalatifard M, Akhtari M, Salehi M, Naderi Z, Jamshidi A, Mostafaei S PMID: 32943404 PMCID: PMC7758541 DOI: 10.1183/13993003.02808-2020 Abstract Introduction: There are no determined treatment agents for severe COVID-19. It is suggested that methylprednisolone, as an immunosuppressive treatment, can reduce the inflammation of the respiratory system in COVID-19 patients. Methods: [...]
Categories: MATH+
Tags: COVID-19, Methylprednisolone
Authors: Ruiz-Irastorza G, Pijoan JI, Bereciatua E, Dunder S, Dominguez J, Garcia-Escudero P PMID: 32960899 PMCID: PMC7508405 DOI: 10.1371/journal.pone.0239401 Abstract Objective: To analyze the effects of a short course of methyl-prednisolone pulses (MP) during the second week of disease (week-2) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia. Methods: Comparative observational study using data [...]
Categories: MATH+
Tags: COVID-19, Methylprednisolone
Authors: Salton F, Confalonieri P, Santus P, Harari S, Scala R, Lanini S et al. PMID: 33072814 PMCID: PMC7543560 DOI: 10.1093/ofid/ofaa421 Abstract Background: In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality. Severe dysregulated systemic inflammation is the [...]
Categories: MATH+
Tags: COVID-19, Methylprednisolone
Authors: Liu J, Zheng X, Huang Y, Shan H, Huang J PMID: 32479759 PMCID: PMC7256545 DOI: 10.1016/j.jaci.2020.05.021 Abstract As of April 4, 2020, a total of 1,051,635 coronavirus disease 2019 (COVID-19) cases had been reported worldwide, among which 56,985 deaths occurred (5.42%).1 However, to date, no vaccine and no specific antiviral medicine are available to [...]
Categories: MATH+
Tags: COVID-19, Methylprednisolone