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Auhtors: Veglia F, Sanseviero E, Gabrilovich DI PMID: 34620838 PMCID: PMC8497485 DOI: 10.1038/s41392-021-00670-9 Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature myeloid cells with immunosuppressive effects, which undergo massive expansion during tumor progression. These cells not only support immune escape directly but also promote tumor invasion via various non-immunological activities. Besides, this [...]
Categories: Cancer Care
Tags: Myeloid Cells
Auhtors: Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, et al. PMID: 20631080 PMCID: PMC4675145 DOI: 10.1158/0008-5472.CAN-10-0706 Abstract The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice [...]
Categories: Cancer Care
Tags: Myeloid Cells, Tumor
Auhtors: Law AMK, Valdes-Mora F, Gallego-Ortega D PMID: 32121014 PMCID: PMC7140518 DOI: 10.3390/cells9030561 Abstract The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes. However, response rates from immunotherapy have been reported to be varied, with some having pronounced [...]
Categories: Cancer Care
Tags: Cancer, Myeloid Cells
Auhtors: Majety M, Runza V, Lehmann C, Hoves S, Ries CH PMID: 28941174 DOI: 10.1111/febs.14277 Abstract Despite decades of research, cancer remains a devastating disease and new treatment options are needed. Today cancer is acknowledged as a multifactorial disease not only comprising of aberrant tumor cells but also the associated stroma including tumor vasculature, fibrotic [...]
Categories: Cancer Care
Tags: Myeloid Cells
Auhtors: Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, et al. PMID: 27381735 PMCID: PMC4935811 DOI: 10.1038/ncomms12150 Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both [...]
Categories: Cancer Care
Tags: Myeloid Cells, Tumor
Auhtors: Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhytyak Z, Cho C PMID: 26717410 PMCID: PMC4696735 DOI: 10.1371/journal.pbio.1002330 Abstract During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional [...]
Categories: Cancer Care
Tags: Breast Cancer, Myeloid Cells
Auhtors: Beury DW, Parker KH, Nyandjo M, Sinha P, Carter KA, Ostrand-Rosenberg S PMID: 25170116 PMCID: PMC4226789 DOI: 10.1189/jlb.3A0414-210R Abstract MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells [...]
Categories: Cancer Care
Tags: Macrophages, Myeloid Cells, Tumor
Auhtors: Pan PY, Ma G, Weber KJ, Ozao-Choy J, Wang G, Yin B, et al. PMID: 19996287 PMCID: PMC2805053 DOI: 10.1158/0008-5472.CAN-09-1882 Abstract Immune tolerance to tumors is often associated with accumulation of myeloid-derived suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In tumor-bearing mice, MDSCs can themselves facilitate the generation [...]
Categories: Cancer Care
Tags: Myeloid Cells, T Regulatory Cells
Auhtors: Huang B, Pan PY, Li Q, Sato AI, Levy DE, Bromberg J, et al. PMID: 16424049 DOI: 10.1158/0008-5472.CAN-05-1299 Abstract The accumulation of myeloid suppressor cells (MSCs) is associated with immune suppression in tumor-bearing mice and in cancer patients. The suppressive activity of MSC correlates with the expression of the myeloid markers Gr-1, CD115 (macrophage [...]
Categories: Cancer Care
Tags: Myeloid Cells
Auhtors: Zea AH, Rodriguez PC, Atkins MB, Hernandez C, Signoretti S, Zabaleta J, et al. PMID: 15833831 DOI: 10.1158/0008-5472.CAN-04-4505 Abstract Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. These cells, described as macrophages or immature dendritic cells, deplete arginine and impair T cell [...]
Categories: Cancer Care
Tags: Myeloid Cells, Tumor