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Auhtors: Cassetta L, Pollard JW PMID: 32208142 DOI: 10.1016/j.cub.2020.01.031 Abstract Cassetta and Pollard introduce tumor-associated macrophages and discuss their origin, diversity, function and plasticity. Keywords: tumor, tumor-associated macrophages Source: https://pubmed.ncbi.nlm.nih.gov/32208142/ Archive: https://archive.is/HUVcb
Categories: Cancer Care
Tags: Tumor
Auhtors: Li X, Liu R, Su X, Pan Y, Han X, Shao C, Shi Y PMID: 31805946 PMCID: PMC6894344 DOI: 10.1186/s12943-019-1102-3 Abstract Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients [...]
Categories: Cancer Care
Tags: Immunotherapy, Macrophages, Tumor
Auhtors: Wu T, Wu X, Wang HY, Chen L PMID: 30999966 PMCID: PMC6471962 DOI: 10.1186/s40880-019-0365-9 Abstract Tumor immune microenvironment is closely related to tumor initiation, prognosis, and response to immunotherapy. The immune landscapes, number of infiltrating immune cells, and the localization of lymphocytes in the tumor vary in across different types of tumors. The immune [...]
Categories: Cancer Care
Tags: Immunotherapy, Tumor
Auhtors: D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, GarcÃa CP, et al. PMID: 30936462 DOI: 10.1038/s41388-019-0803-9 Abstract Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown that tumor-associated macrophage (TAM) infiltration increases following chemotherapy in PDAC. Since one [...]
Categories: Cancer Care
Tags: Macrophages, Pancreatic Cancer, Tumor
Auhtors: Awad RM, De Vlaeminck Y, Maebe J, Goyvaerts C, Breckpot K PMID: 30233579 PMCID: PMC6127274 DOI: 10.3389/fimmu.2018.01977 Abstract Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages, dendritic cells [...]
Categories: Cancer Care
Tags: Tumor
Auhtors: Gyori D, Lim EL, Grant FM, Spensberger D, Roychoudhuri R, Shuttleworth SJ, et al. PMID: 29875321 PMCID: PMC6124419 DOI: 10.1172/jci.insight.120631 Abstract Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we [...]
Categories: Cancer Care
Tags: Immunotherapy, Macrophages, Tumor
Auhtors: Blum A, Wang P, Zenklusen JC PMID: 29625059 DOI: 10.1016/j.cell.2018.03.059 Abstract This SnapShot provides a list of the tumor types characterized by The Cancer Genome Atlas (TCGA) program. Key findings shown are the most relevant discoveries described in each marker paper for the tumor type. Keywords: cancer, tumors Source: https://pubmed.ncbi.nlm.nih.gov/29625059/ Archive: https://archive.ph/REF1b [...]
Categories: Cancer Care
Tags: Tumor
Auhtors: Kitano Y, Okabe H, Yamashita YI, Nakagawa S, Saito Y, Umezaki N, et al. PMID: 29123259 PMCID: PMC5785749 DOI: 10.1038/bjc.2017.401 Abstract Background: Inflammation and immune characteristics of the tumour microenvironment have therapeutic significance. The aim of this study was to investigate the clinical impact on disease progression in human extrahepatic cholangiocarcinoma (ECC). Methods: A [...]
Categories: Cancer Care
Auhtors: Liu S, Chen S, Zeng J PMID: 29115550 DOI: 10.3892/mmr.2017.7970 Abstract Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TGF‑β) [...]
Categories: Cancer Care
Tags: Tumor
Auhtors: Yuan X, Zhang J, Li D, Mao Y, Mo F, Du W, Ma X PMID: 28698008 DOI: 10.1016/j.ygyno.2017.07.007 Abstract Objective: The role of tumor-associated macrophages (TAMs) in tumor microenvironment remains controversial due to the two different polarized subsets of TAMs. Here, we performed a meta-analysis to evaluate the correlation between subpopulations of TAMs and [...]
Categories: Cancer Care
Tags: Macrophages, Ovarian Cancer, Tumor