Authors: Shodell M, Siegal FP
PMID: 11544466 DOI: 10.1067/mai.2001.117928
Abstract
Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that steroid administration results in a decrease of IFN-alpha generation of approximately 25-fold, accompanied by reduction in circulating plasmacytoid dendritic cell numbers. Both parameters return to normal within days after steroid cessation.
Keywords: corticosteriods, plasmacytoid dendritic cells, Glucocorticoids, immunosuppressive, IFN-alpha
Source: https://pubmed.ncbi.nlm.nih.gov/11544466/
Archive: https://archive.ph/cJXPd
