In this review of research, we find that SARS-COV-2 (possibly directly) and COVID-19 vaccines (possibly indirectly, via anti-idiotype antibodies) can change the neuron gene expressions in the sensory ganglions. Additionally, there is a possibility of ganglion pathology due to peripheral nerve injury and systemic inflammatory molecules in the circulation. Satellite glial cells, macrophages, and other immune cells could become activated in the ganglions resulting in neuronal hyperexcitability and hyperesthesia and allodynia. Let’s review.